Structure of PDB 5mrc Chain D Binding Site BS01

Receptor Information

>5mrc Chain D (length=252) Species: 4932 (Saccharomyces cerevisiae)

LNPLPNAAIPPKYALVTVRSFPSLEPLTFVPVPTSTVAAPLRRDILWRAV
VYENDNRRVGASNPPGRSENGFSRRKLMPQKGSGRARVGDANSPTRHNGG
RALARTAPNDYTTELPSKVYSMAFNNALSHQYKSGKLFVIGGEKVDLISP
TPELDLNRLDLVNTNTVEGKEIFEGEVIFRKFLEEFQLKGKRLLFITDKT
REGLIKSSDPYKQKVDVIQKELVEVNDILRAQAVFIELEALEYLAMAHQK
EI

Ligand information

>5mrc Chain A (length=2709)

guagaauaauagauuugaaauauuuauuauauagauuuaaagagauaauc
auggaguauaauaauuaaauuuaauuuaauauaacuauuaauagaagguu
acuaauaaauuaauaauuaauuuuaaaaccuaaagguaaaccuuuauauu
aauaauguuaugaauaauuauuaauaauaauaaacuaagugaacugaaac
aucuaaguaacuuaaggauaagaaaucaacagagauauuaugaguauugg
ugagagaaaauaauaaaggucuaauaaguauuaugugaaaaaaauguaag
aaaauaggauaacaaauucuaagacuaaauacuauuaauaaguauaguaa
guaccguaagggaaaguaugaaaaugauuauuuuauaagcaaucaugaau
auauuauauuauauuaaugauguaccuuuuguauaaugggucagcaagua
auuaauauuaguaaaacaauaaguuauaaauaaauagaauaauauauaua
uauaaaaaaauauauauuuaauuaauauuaauugacccgaaagcaaacga
ucuaacuaugauaagauggauaaacgaucgaacagguugauguugcaaua
ucaucugauuaauugugguuaguagugaaagacaaaucugguuugcagau
agcugguuuucuaugaaauauauguaaguauagccuuuauaaauaauaau
uauuauauaauauauuauauaaagaaugguacagcaauuaauauauauua
gggaacuaguuuuuuaauaauauuaaaucucgaaauauuuaauuauauau
aauaaagagucagauuaugugcgauaagguaaauaaucuaaagggaaaca
gcccagauuaagauauaaaguuccuaauaaauaauaagugaaauaaauau
uaaaauaaauauuuaaaaucaaauauauauauauuuguuaauagauaaua
uacggaucuuaauaauaagaauuauuuaauuccuuggaauauuauauuuu
aaaauauaaauacugaauaucuaaauauuauuauuauaauaauaauaaua
ugguaauagaacauuuaaugauaauauauauuaguuauuaauuaauauau
guauuaauuaaauagagaaugcugacaugaguaacgaaaaaaagguauaa
accuuuucaccuaaaacauaagguuuaacuauaaaaguacggccccuaau
uaaauuaaauauaaauauauuuaagaugggauaaucuauauuaauauuua
ucuuaaaauauauaauuauauuauauauuauauauuuauauaauauaaac
uaauaaagaucaggaaaauuaauguauaccguaauguagaccgacucagg
uauguaaguagagaauaugaaggugaauuagauaauuaaagggaaggaac
ucggcaaagauagcucauaaguuagucaauaaagaguaauaagaacaaag
uuguacaacuguuuacuaaaaacaccgcacuuugcagaaacgauaaguuu
aaguauaaggugugaacucugcuccaugcuuaauauauaaauaaaauuau
uuaacgauaauuuaauuaaauuuagguaaauagcagccuuauuaugaggg
uuauaauguagcgaaauuccuuggccuauaauugaggucccgcaugaaug
acguaaugauacaacaacugucuccccuuuaagcuaagugaaauugaaau
cguagugaagaugcuauguaccuucagcaagacggaaagacccuaugcag
cuuuacuguaauuagauagaucgaauuauuguuuauuauauauaaugaua
auucuaaucuuauacuuaauucuuaaguaauauauaauauauauauauau
uauauauuauaagagacaaucucuaauugguaguuuugauggucauuauc
agcaaaaguaucugaauaaguccauaaauaaauauauaaaauuauugaaa
aaaauaauauauauuauauauauuaauuauaaauugaaauauguuuaauu
gaauauauuuuaguaauagauaaaaauauguacaguaaaauuguaaggaa
aacaauaauaacuuucucggaaagaauuaaauuaauauaaugguauaacu
gugcgauaauuguaacacaaacgagugaaacaaguacguaaguauggcau
aaugaacaaauaacacugauuguaaagguuauugauaacgaauaaaaguu
acgcuagggaaggguaauauagcgaaagaguagauauuguaagcuauguu
ugccaccuucgacucaacauuuccucuugguuguaaaagcuaagaagggu
uugacuguucgucaauuaaaauguuacgugaguuggguuaaauacgaugu
gaaucaguaugguuccuaucugcugaaggaaauauuaucaaauuaaaucu
cauuauuaguacgcaaggaccauaaugaaucaacccaugguguaucuauu
gauaauaauauaauauauuuauuaauauauuaucuauauuaguuuauauu
uuaauuauuaucauaguagauaagcuaaguugauaauaaauaaauauuga
auacauauuaaauaugaaguuguuuuaauaagauaauuaaucugauaauu
uuauacuaaaauuaauaauuauagguuuuauauauuauuuauaauuauaa
uauuaauaaaauacuaauuuaucaguuaucuauauaauaucuaaucuauu
auucuauau

<<<<<<<<<<<<<<<.<<......<<<<<<<<<<<<.....<<<<<<<<<
<<...<<<<....<<<<<<<<.>>>>>>>>...<<<<<<<<<<..<<<<.
......<<<<<<<...>>>>>>>....>>>>..<<<....>>>....<<<
<<<<<<..<....>..>>>>>>>>>.........<<<<<<.....<<...
.>>......>>>>>.>..<<.....<<....>>..<<<<<<.....<<..
...>>....>>>>>>...<<<.........<<<<<<.......>>>>>>.
.....<<<<..((((.>>>>..>>>....>>.>>>>>>>>.>>.......
...<<....>>....>>>>....>>>>>>>>>>>.......<<<<<.<<<
<<<......>>>>>>.>>>>>...<.<........>.>.<<<<<<....<
<<<<<<<<<<<<..<<<.....>>>....................<<<<.
<......>.>>>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<..
..<<<<<<<<<<..<<<<......>.>>>...<<<..<<<<........>
>>>.>>>....>>>>>>>>>>...<<.....>>.......>>>>>>...>
..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<
<<<<<<<<<<<..>>>>>>>>>..<<<<...<<<...<<<<<<<.<<<<<
<<<<<<<>>>>>>>>>>>>>>>>>>>..>>.>...>>>>>>>>>>>...>
.>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<.....
.>>>...<<<.<<<<...<<<(((...<<<<<<<.....<<......<<<
<<<<<<<..>>>>>.....<<<<<<<<..>>>>>>>>.>>>>>.......
...)))>>.............>>>>>>><<<<<..>>>>>.<<<<<<<<.
.>>>>>>>>..>>>...>>>>>>><<<<<<<<<<<<...>>>>>>>>>>>
>....>>>>>>..<<<<<<......<<<<<<<<<<<...>>>>>>>>>>>
......>>>>>>........>>>>>><......<<....<<<<<<.....
.>>>>>><<<<<...<<<<<.<.............((..<<<.<<<...<
<<...<..<<<<..>>>>>..>>>...>>>.....)).<<<<<<<.<<<.
....<<.<<<......>>>.>>.<<<<<<<<<<<..>>>>>>>>>.[[..
>>....>>>........>>>>>>>....>>>...>.....<<......>>
>>>>>..<<<.....>>>..>>>>>..<<<<....<<<<<<<<.<<....
.............<<<....<.....>......>>>.............<
<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>
......>>>>>>>..<<<<.<<<..<<<<<<<<.<<.....<.<<<<<<<
<....>>>>>>>>>.....>>>>>>>>..>>>>><<<<<........>>>
>>........<...........<<<<<.......>>>>>.....>....>
>.>>..>>.>>>>>>......>>.>>>>>>>>.>>>>>>.....>.....
<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<
<<..<<<<.<<<<<<<..<<<.<<<<<<<<<<<.<<.....>>>>>>>>>
>>>>...<<<<<<<<<.<....>.>.>>.<<<<<<<<<<<<<..>>>>>>
>>>>>>>.>>>>>>....>>>>>>>>>>..>>>>..<<<<.>>>><<<<<
<...........>>>.>>>..<<....<<<.....<<<....>>>.....
.....<<<<<<<.....>>>>>>>...>>>.....<<<<<<<<<<<....
>>>>>>>>>>>.................<<<<<<<....<<<<<......
.>>>>><<<..<<<<<<.>>>>>>.>>>......<<.[.(((>>....>>
>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))
].......<<<<<<.<<..))))..>>>>>>>>.............>>>>
..>>>>>>>..<<<<.<.<<<<<....<<.......>>....>>>>>...
>>>>.>..<<<<<..<<<<<..<<<<<<<<<.......>>>>>>>..>>.
<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<..
..>>>.>>>>...>>>..>>>>>>>>>>>.....<<<<<..<<<<<<..<
<<<<<<...............>>>>>>><<<<<<....<<<..<<<<<<<
<<<<<<<<.<<<<<<<<<<....>>>>>>>>>>..<<<<...]].>>>>.
....>>>>>>>>>..>>>>>>..>>>..>>>>>>..<<<.<..<<<<<..
..........>>>>>...>>>>.>>>>>>..>>>>>.....<<<<<<<<<
<.......>>>>>........<<<<<<<<<<..<<...<<<<<..>>>>>
.>>..>>>>>>>.>>>....>>>>>..>>>>>>>>>>>>>>.>>>>>>>>
>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5mrc The structure of the yeast mitochondrial ribosome.
• Resolution: 3.25 Å
• Binding residue (original residue number in PDB): R70 W75 R76 N82 R86 V87 A89 S90 N91 P92 R95 S96 F100 S101 R102 R103 K104 Q108 K109 G110 R113 A114 R115 G117 P122 T123 R124 H125 R129 L131 R133 A135 P136 E142 P144 S145 K146 V147 M150 R208 K217 R220 P238 Y239 R258
• Binding residue (residue number reindexed from 1): R42 W47 R48 N54 R58 V59 A61 S62 N63 P64 R67 S68 F72 S73 R74 R75 K76 Q80 K81 G82 R85 A86 R87 G89 P94 T95 R96 H97 R101 L103 R105 A107 P108 E114 P116 S117 K118 V119 M122 R180 K189 R192 P210 Y211 R230

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:5mrc, PDBe:5mrc, PDBj:5mrc
• PDBsum: 5mrc
• PubMed: 28154081
• UniProt: P51998|RL4P_YEAST Large ribosomal subunit protein uL4m (Gene Name=YML6)