Structure of PDB 5lds Chain D Binding Site BS01

Receptor Information
>5lds Chain D (length=898) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRFICQEP
TDVIIIHSKKLNYTHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSL
QPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKS
FPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFE
TTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALNV
TGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLFD
PQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYL
GADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISE
MFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEH
LQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLLD
SESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDD
WVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNL
ATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPM
KKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQC
ENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQ
AQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIAS
NVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQL
EQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
Ligand information
Ligand IDBMA
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-RWOPYEJCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-mannopyranose;
beta-D-mannose;
D-mannose;
mannose
ChEMBL
DrugBank
ZINCZINC000003830679
PDB chain5lds Chain E Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lds Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		T288 A289
Binding residue
(residue number reindexed from 1)		T223 A224
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E350 H383 E384 H387 E406 S464 Y472
Catalytic site (residue number reindexed from 1) E285 H318 E319 H322 E341 S399 Y407
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0043171 peptide catabolic process
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5lds, PDBe:5lds, PDBj:5lds
PDBsum5lds
PubMed28393915
UniProtP15145|AMPN_PIG Aminopeptidase N (Gene Name=ANPEP)

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