Structure of PDB 5lb8 Chain D Binding Site BS01

Receptor Information

>5lb8 Chain D (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLC
YQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKE
LLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHC
VSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLKK
PVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKACGIVYCRTREAC
EQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFDKA
NVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIR
KEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGDALPA
CAKGCDHCQNPTAVRRRLEALERSSS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5lb8 Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5lb8 Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	C411 C431
Binding residue (residue number reindexed from 1)	C385 C405
Annotation score	1

Enzymatic activity

Enzyme Commision number

5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding

	Biological Process
GO:0006310	DNA recombination

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Molecular Function

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Biological Process

External links

PDB	RCSB:5lb8, PDBe:5lb8, PDBj:5lb8
PDBsum	5lb8
PubMed	28100692
UniProt	O94762\|RECQ5_HUMAN ATP-dependent DNA helicase Q5 (Gene Name=RECQL5)

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