Structure of PDB 5l0q Chain D Binding Site BS01

Receptor Information
>5l0q Chain D (length=195) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLASGQPICGNGMVEQGEECDCGYSDQCKDECCYDANQPEGKKCKLKPGK
QCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGITALCPASDPKPN
FTDCNRHTQVCINGQCAGSICEKHGLEECTCASDDKELCHVCCMKKMEPS
TCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRGSAS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5l0q Chain D Residue 704 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5l0q An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
Resolution2.759 Å
Binding residue
(original residue number in PDB)		I459 N462 M464 E466 E469 D472
Binding residue
(residue number reindexed from 1)		I8 N11 M13 E15 E18 D21
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.81: ADAM10 endopeptidase.
External links
PDB RCSB:5l0q, PDBe:5l0q, PDBj:5l0q
PDBsum5l0q
PubMed27503072
UniProtQ10741|ADA10_BOVIN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

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