Structure of PDB 5jhq Chain D Binding Site BS01

Receptor Information

>5jhq Chain D (length=463) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRK
DVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD
NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAV
LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY
NRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN
AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE
LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCA
VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK
HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQ
MGNEAVQQILSES

Ligand information

>5jhq Chain K (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YRQSPDGACS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R215 S217 F222 G225 F226 L250 N255 S258 F259 H261 D279 W281 Y283 E288
Binding residue (residue number reindexed from 1)	R36 S38 F43 G46 F47 L71 N76 S79 F80 H82 D100 W102 Y104 E109

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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