Structure of PDB 5igq Chain D Binding Site BS01

Receptor Information
>5igq Chain D (length=324) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFQECLSKFTRYNSVRPLATLSYALYNGSSIVSSIEFDRDCDYFAIAGVT
KKIKVYEYDTVIQDAIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGT
VILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMV
FKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKN
FVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVNEFVSAVCWRA
LPDGESNVLIAANSQGTIKVLELV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5igq Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		V441 K472 Y491 W517 N557 C559 H578 A601 T618 K643 N644 F645
Binding residue
(residue number reindexed from 1)		V49 K78 Y97 W123 N163 C165 H184 A207 T224 K249 N250 F251
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0061630 ubiquitin protein ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5igq, PDBe:5igq, PDBj:5igq
PDBsum5igq
PubMed27041596
UniProtQ8NHY2|COP1_HUMAN E3 ubiquitin-protein ligase COP1 (Gene Name=COP1)

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