Structure of PDB 5ic6 Chain D Binding Site BS01

Receptor Information
>5ic6 Chain D (length=90) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQI
LTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYF
Ligand information
Receptor-Ligand Complex Structure
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PDB5ic6 Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Y230 S231 W232 R233 S234 S275 Q276
Binding residue
(residue number reindexed from 1)		Y19 S20 W21 R22 S23 S64 Q65
Enzymatic activity
Enzyme Commision number 3.4.22.60: caspase-7.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5ic6, PDBe:5ic6, PDBj:5ic6
PDBsum5ic6
PubMed27367566
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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