Structure of PDB 5hud Chain D Binding Site BS01

Receptor Information

>5hud Chain D (length=457) Species: 1718 (Corynebacterium glutamicum)

HHSSGMSWTVDILPEGMQQQFEDTISRDAKQQPTWDRAQAENVRKILESV
PPIVVAPEVLELKQKLADVANGKAFLLQGGDCAETFESNTEPHIRANVKT
LLQMAVVLTYGASTPVIKMARIAGQYAKPRSSDLDGNGLPNYRGDIVNGV
EATPEARRHDPARMIRAYANASAAMNLVRALTSSGTADLYRLSEWNREFV
ANSPAGARYEALAREIDSGLRFMEACGVSDESLRAADIYCSHEALLVDYE
RSMLRLATDEEGNEELYDLSAHQLWIGERTRGMDDFHVNFASMISNPIGI
KIGPGITPEEAVAYADKLDPNFEPGRLTIVARMGHDKVRSVLPGVIQAVE
ASGHKVIWQSDPMHGNTFTASNGYKTRHFDKVIDEVQGFFEVHRALGTHP
GGIHIEFTGEDVTECLGGAEDITDVDLPGRYESACDPRLNTQQSLELAFL
VAEMLRN

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5hud Chain D Residue 525

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5hud Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): C97 H379 E421 D451
• Binding residue (residue number reindexed from 1): C82 H364 E406 D436
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.

Gene Ontology

Molecular Function

• GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008652 amino acid biosynthetic process
• GO:0009073 aromatic amino acid family biosynthetic process
• GO:0009423 chorismate biosynthetic process

External links

• PDB: RCSB:5hud, PDBe:5hud, PDBj:5hud
• PDBsum: 5hud
• PubMed: 29178787
• UniProt: Q8NNL5