Structure of PDB 5ed2 Chain D Binding Site BS01

Receptor Information
>5ed2 Chain D (length=385) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKD
AKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYL
NNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILE
EPADRHPNRKARGQLRTKIESGQGTIPVRSNASIQTWDGVLQGERLLTMS
CSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRIS
NIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINAT
TGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAA
KEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>5ed2 Chain E (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcucgcgaugcuggagggcucug
.......................
Receptor-Ligand Complex Structure
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PDB5ed2 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		T375 K376 H394 E396 P450 C451 R455 H460 H471 R474 K475 S486 G487 Q488 G489 C516
Binding residue
(residue number reindexed from 1)		T60 K61 H79 E81 P135 C136 R140 H145 H156 R159 K160 S171 G172 Q173 G174 C201
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5ed2, PDBe:5ed2, PDBj:5ed2
PDBsum5ed2
PubMed27065196
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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