Structure of PDB 5dx1 Chain D Binding Site BS01

Receptor Information
>5dx1 Chain D (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDF
KDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTD
RIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSG
NMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE
YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGL
VHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDT
LSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5dx1 Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Resolution1.93 Å
Binding residue
(original residue number in PDB)		F152 Y153 N161 M162 E257 M259 Y261 E266 L412 H414 Y416 F474 Y476
Binding residue
(residue number reindexed from 1)		F19 Y20 N28 M29 E124 M126 Y128 E133 L279 H281 Y283 F341 Y343
Enzymatic activity
Catalytic site (original residue number in PDB) D165 E257 E266 H414
Catalytic site (residue number reindexed from 1) D32 E124 E133 H281
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5dx1, PDBe:5dx1, PDBj:5dx1
PDBsum5dx1
PubMed26551522
UniProtQ86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 (Gene Name=CARM1)

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