Structure of PDB 5dx0 Chain D Binding Site BS01

Receptor Information

>5dx0 Chain D (length=343) Species: 9606 (Homo sapiens)

SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFK
DKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDR
IVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGN
MFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY
FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLV
HGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTL
SGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT

Ligand information

>5dx0 Chain I (length=9) Species: 9606 (Homo sapiens)

GKAPRKQLA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5dx0 Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): F152 Y153 N161 D165 E257 M259 Y261 N265 E266 H414 Y416
• Binding residue (residue number reindexed from 1): F18 Y19 N27 D31 E123 M125 Y127 N131 E132 H280 Y282

Enzymatic activity

• Catalytic site (original residue number in PDB): D165 E257 E266 H414
• Catalytic site (residue number reindexed from 1): D31 E123 E132 H280
• Enzyme Commision number: 2.1.1.319: type I protein arginine methyltransferase.

Gene Ontology

Molecular Function

• GO:0016274 protein-arginine N-methyltransferase activity

Biological Process

• GO:0018216 peptidyl-arginine methylation

External links

• PDB: RCSB:5dx0, PDBe:5dx0, PDBj:5dx0
• PDBsum: 5dx0
• PubMed: 26551522
• UniProt: Q86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 (Gene Name=CARM1)