Structure of PDB 5d98 Chain D Binding Site BS01

Receptor Information
>5d98 Chain D (length=693) Species: 100673 (Influenza C virus (C/Johannesburg/1/66)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDEYL
STNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQFV
EIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKLRI
FSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVPLPF
QTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRLPK
GPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPKDK
PLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGRASKKIPEISL
TQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVPMAEYP
PADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRLFPGK
IKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHDGMYTIITFEF
SIREPNLEKHQKYTVFEAGHTTVRMKKREVPLYLYCRTTALSKIKNDWLS
KARRCFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGELIAQ
PLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKSSFGF
NPEGLLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFKT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5d98 Chain D Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5d98 Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		H41 D93 E104
Binding residue
(residue number reindexed from 1)		H38 D90 E101
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5d98, PDBe:5d98, PDBj:5d98
PDBsum5d98
PubMed26503046
UniProtQ9IMP5|PA_INCJH Polymerase acidic protein (Gene Name=PA)

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