Structure of PDB 5d0j Chain D Binding Site BS01
Receptor Information
>5d0j Chain D (length=104) Species:
9606
(Homo sapiens) [
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AIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCH
LQKVKHYLILPSEEERLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLR
HCCT
Ligand information
>5d0j Chain M (length=8) Species:
32630
(synthetic construct) [
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SFEGYDNS
Receptor-Ligand Complex Structure
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PDB
5d0j
Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
R438 R462 N463 K478 H479 Y480 L481 M495
Binding residue
(residue number reindexed from 1)
R15 R39 N40 K55 H56 Y57 L58 M71
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5d0j
,
PDBe:5d0j
,
PDBj:5d0j
PDBsum
5d0j
PubMed
27257138
UniProt
Q14451
|GRB7_HUMAN Growth factor receptor-bound protein 7 (Gene Name=GRB7)
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