Structure of PDB 5am8 Chain D Binding Site BS01

Receptor Information

>5am8 Chain D (length=612) Species: 9606 (Homo sapiens)

LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAEN
ARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGS
ANLPLAKRQQYNALLSQMSRIYSTAKVCLPNKATCWSLDPDLTNILASSR
SYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSW
YNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAH
LLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFF
TSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRV
TMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVST
PEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFS
GRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRY
FVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRP
WQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHP
PLPDNYPEGIDL

Ligand information

>5am8 Chain S (length=2) Species: 9606 (Homo sapiens)

DS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5am8 The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): Q259 H331 T358 E362 F435 K489 H491 Y498 Y501
• Binding residue (residue number reindexed from 1): Q258 H330 T357 E361 F434 K488 H490 Y497 Y500

Enzymatic activity

• Catalytic site (original residue number in PDB): H331 A332 H361 E362 H365 E389 H491 Y501
• Catalytic site (residue number reindexed from 1): H330 A331 H360 E361 H364 E388 H490 Y500
• Enzyme Commision number: 3.4.15.1: peptidyl-dipeptidase A.

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008241 peptidyl-dipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5am8, PDBe:5am8, PDBj:5am8
• PDBsum: 5am8
• PubMed: 26748546
• UniProt: P12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)