Structure of PDB 4ywt Chain D Binding Site BS01

Receptor Information
>4ywt Chain D (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLA
NRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPG
AFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQL
HPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLG
VASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKG
CLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINAL
QDNRDTLTAKVIQGCGNPKVNRGKLAPRERPPSGTLEKLVSEAKAQLRDV
QDFWISLPGTLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVD
ITKPDMTIRQQIMQLKIMTNRLRSAYNGN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4ywt Chain D Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ywt Structural Aspects of N-Glycosylations and the C-terminal Region in Human Glypican-1.
Resolution2.38 Å
Binding residue
(original residue number in PDB)		I437 E443
Binding residue
(residue number reindexed from 1)		I392 E398
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
GO:0043236 laminin binding
Biological Process
GO:0009966 regulation of signal transduction
GO:0014037 Schwann cell differentiation
GO:0016477 cell migration
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0032288 myelin assembly
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:1905475 regulation of protein localization to membrane
GO:2001016 positive regulation of skeletal muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005796 Golgi lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0043202 lysosomal lumen
GO:0045121 membrane raft
GO:0045202 synapse
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ywt, PDBe:4ywt, PDBj:4ywt
PDBsum4ywt
PubMed26203194
UniProtP35052|GPC1_HUMAN Glypican-1 (Gene Name=GPC1)

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