Structure of PDB 4ynq Chain D Binding Site BS01

Receptor Information
>4ynq Chain D (length=224) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPHGHMQTLIFLNLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWK
PQALLQWVDEHARPFSTVKPMYGT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ynq Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E20 L24 N125 R128 Y129 S176 Y177 S178
Binding residue
(residue number reindexed from 1)		E16 L20 N121 R124 Y125 S165 Y166 S167
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:4ynq, PDBe:4ynq, PDBj:4ynq
PDBsum4ynq
PubMed25848017
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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