Structure of PDB 4yjl Chain D Binding Site BS01

Receptor Information
>4yjl Chain D (length=339) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPA
VCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRR
YAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLR
NLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHC
TENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATN
EDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALW
DMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4yjl Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E578 D610
Binding residue
(residue number reindexed from 1)		E179 D211
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4yjl, PDBe:4yjl, PDBj:4yjl
PDBsum4yjl
PubMed27462415
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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