Structure of PDB 4xgv Chain D Binding Site BS01

Receptor Information

>4xgv Chain D (length=305) Species: 83333 (Escherichia coli K-12)

TEVTVLEGKTMGTFWRASIPGIDAKRSAELKEKIQTQLDADDQLLSTYKK
DSALMRFNDSQSLSPWPVSEAMADIVTTSLRIGAKTDGAMDITVGPLVNL
WGFGPEQQPVQIPSQEQIDAMKAKTGLQHLTVINQSHQQYLQKDLPDLYV
DLSTVGEGYAADHLARLMEQEGISRYLVSVGGALNSRGMNGEGLPWRVAI
QKPQAVVDINGHGISTSGSYRNYKRLSHVIDPQTGRPIEHNLVSVTVIAP
TALEADAWDTGLMVLGPEKAKEVVRREGLAVYMITKEGDSFKTWMSPQFK
SFLVS

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4xgv Chain D Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4xgv Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.
• Resolution: 1.883 Å
• Binding residue (original residue number in PDB): T166 D280 D283 T284
• Binding residue (residue number reindexed from 1): T154 D256 D259 T260
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.180: FAD:protein FMN transferase.

Gene Ontology

Molecular Function

• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0017013 protein flavinylation

Cellular Component

• GO:0005886 plasma membrane
• GO:1990204 oxidoreductase complex

External links

• PDB: RCSB:4xgv, PDBe:4xgv, PDBj:4xgv
• PDBsum: 4xgv
• PubMed: 26626129
• UniProt: P0AB85|APBE_ECOLI FAD:protein FMN transferase (Gene Name=apbE)