Structure of PDB 4wqs Chain D Binding Site BS01

Receptor Information
>4wqs Chain D (length=1151) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFG
PIKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAH
IWFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQ
LLTDEEYRELRYARMGAEAIQQLLKELDLEALEKELLEEMKHPSRARRAK
ARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDLN
DLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPV
TNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQ
CGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRDIKDEVWDAL
EEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFD
GDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYY
ITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKY
VFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVE
DEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTF
STTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQ
ILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGL
RGLMQKPSGETRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTR
KLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGLYG
RVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQT
RYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTFHTGGV
AGAADITQGLPRVIELFEARRPKAAIDPHQLLEAKGPEAVERYLVEEIQK
VYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEALN
ERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAG
KKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKEAVE
A
Ligand information
Receptor-Ligand Complex Structure
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PDB4wqs The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions.
Resolution4.306 Å
Binding residue
(original residue number in PDB)		R486 A487 R534 A536 R586 K610 R628 A705 P706 Q744 T1088 A1089 Y1093 R1096 F1440 Q1441 N1442
Binding residue
(residue number reindexed from 1)		R195 A196 R243 A245 R295 K319 R337 A414 P415 Q453 T792 A793 Y797 R800 F1086 Q1087 N1088
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wqs, PDBe:4wqs, PDBj:4wqs
PDBsum4wqs
PubMed25601758
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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