Structure of PDB 4uo0 Chain D Binding Site BS01

Receptor Information

>4uo0 Chain D (length=172) Species: 560387 (Influenza A virus (A/equine/Richmond/1/2007(H3N8)))

GIFGAIAGFIENGWEGMVDGWYGFRYQNSEGTGQAADLKSTQTAIDQINE
KLNRVIERTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLV
ALENQHTIDLTDAEMNKLFEKTRRQLRENAEDMGGGCFKIYHKCDNACIG
SIRNGTYDHYIYRDEALNNRFQ

Ligand information

• Ligand ID: FUC
• InChI: InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
• InChIKey: SHZGCJCMOBCMKK-SXUWKVJYSA-N
• SMILES:
  CACTVS 3.341: C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)C
  OpenEye OEToolkits 1.5.0: CC1C(C(C(C(O1)O)O)O)O
  OpenEye OEToolkits 1.5.0: C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
  CACTVS 3.341: C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
• Formula: C6 H12 O5
• Name: alpha-L-fucopyranose;
  alpha-L-fucose;
  6-deoxy-alpha-L-galactopyranose;
  L-fucose;
  fucose
• ChEMBL: CHEMBL1232862
• DrugBank: DB04473
• ZINC: ZINC000001532814
• PDB chain: 4uo0 Chain U Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4uo0 Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): G150 R153
• Binding residue (residue number reindexed from 1): G150 R153
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0046789 host cell surface receptor binding

Biological Process

• GO:0019064 fusion of virus membrane with host plasma membrane

Cellular Component

• GO:0019031 viral envelope

External links

• PDB: RCSB:4uo0, PDBe:4uo0, PDBj:4uo0
• PDBsum: 4uo0
• PubMed: 25024224
• UniProt: C3TUR9