Structure of PDB 4tvv Chain D Binding Site BS01

Receptor Information

>4tvv Chain D (length=288) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1)

IVCDSTIENPCIVQDSKTQFSPVIRYREVASIADVYGGNITGINKFHLSG
SEQPSEKGWEAIAESISRKMGAETKKVIVLDLRQESHGYLNGRAITLVSA
YNWINLGKSNSQSTLDQENWLAGLRSRKIVNGVLTVPQYVAKQYSQGKSM
VVSTVKNEEYYVYKKGFDYYRIFISDHRAPLDSEVDALVALIKNNPEDTW
YHVHCRGGKGRTTTVFAMFDMLKNADKVSFEEIIARQASIPPFYNLMVTN
REIPELTPYYEQRLQFLIHFYEFARQSLMGYSGTWSEW

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 4tvv Chain D Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4tvv A Type IV Translocated Legionella Cysteine Phytase Counteracts Intracellular Growth Restriction by Phytate.
• Resolution: 1.4 Å
• Binding residue (original residue number in PDB): H203 G236 Y270 R277 Y286
• Binding residue (residue number reindexed from 1): H177 G210 Y244 R251 Y260
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0004725 protein tyrosine phosphatase activity

Biological Process

• GO:0016311 dephosphorylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4tvv, PDBe:4tvv, PDBj:4tvv
• PDBsum: 4tvv
• PubMed: 25339170
• UniProt: Q5ZRR1