Structure of PDB 4qtu Chain D Binding Site BS01

Receptor Information
>4qtu Chain D (length=179) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAHKYTGSTRVQHIQAKMTLRALELLNLQPCSFILDIGCGSGLSGEILTQ
EGDHVWCGLDISPSMLATGLSRELEGDLMLQDMGTGIPFRAGSFDAAISI
SAIQWLCNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDDQVDDILQSA
KVAGFSGGLVVDDPESKKNKKYYLVLSSG
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain4qtu Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4qtu Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.
Resolution2.124 Å
Binding residue
(original residue number in PDB)		Y22 Q32 G55 C56 G57 S61 D77 I78 D99 M100 I117 S118 W122
Binding residue
(residue number reindexed from 1)		Y5 Q15 G38 C39 G40 S44 D60 I61 D82 M83 I100 S101 W105
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.309: 18S rRNA (guanine(1575)-N(7))-methyltransferase.
Gene Ontology
Molecular Function
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016435 rRNA (guanine) methyltransferase activity
Biological Process
GO:0070476 rRNA (guanine-N7)-methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qtu, PDBe:4qtu, PDBj:4qtu
PDBsum4qtu
PubMed25489090
UniProtP25627|BUD23_YEAST 18S rRNA (guanine(1575)-N(7))-methyltransferase (Gene Name=BUD23)

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