Structure of PDB 4qnk Chain D Binding Site BS01

Receptor Information
>4qnk Chain D (length=185) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SARIGEVKRETKETNVSVKINLDGHGVSDSSTGIPFLDHMLDQLASHGLF
DVHVRATGDTHIDDHHTNEDVALAIGTALLKALGERKGINRFGDFTAPLD
EALIHVSLDLSGRPYLGYNLEIPTQRVGTYDTQLVEHFFQSLVNTSGMTL
HIRQLAGKNSHHIIEATFKAFARALRQATESDPRR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4qnk Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4qnk Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		H73 E77 H145
Binding residue
(residue number reindexed from 1)		H65 E69 H137
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
Biological Process
GO:0000105 L-histidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qnk, PDBe:4qnk, PDBj:4qnk
PDBsum4qnk
PubMed26095028
UniProtO23346|HIS5B_ARATH Imidazoleglycerol-phosphate dehydratase 2, chloroplastic (Gene Name=HISN5B)

[Back to BioLiP]