Structure of PDB 4q5s Chain D Binding Site BS01

Receptor Information
>4q5s Chain D (length=1484) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGPI
KDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHIW
FVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQLL
TDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGVA
LYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEILAELPEPYLFRA
EEEGVVELKELEEGAFLVLRREDEPVATYFLPVGMTPLVVHGEIVEKGQP
LAEAKGLLRMPRQVRAAQVEAEEEGETVYLTLFLEWTEPKDYRVQPHMNV
VVPEGARVEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPF
EDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESYDID
ARMGAEAIQQLLKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFL
DSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR
LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSL
TDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELF
KPFLLKKMEEKGIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLN
RAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS
FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAG
LEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYVFANPDEALLAV
AHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELIQLD
VPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD
AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKV
TQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLRGLMQKPSGETF
EVPVRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVTH
EIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV
EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQK
CYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMQGLPRVIELFEARRP
KAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDY
VEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHI
EIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWK
PLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVIL
GRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKEA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4q5s Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R586 K610 R615 R622 R628 A705 T1088 A1089 G1092 Y1093 N1442
Binding residue
(residue number reindexed from 1)		R583 K607 R612 R619 R625 A702 T1085 A1086 G1089 Y1090 N1424
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4q5s, PDBe:4q5s, PDBj:4q5s
PDBsum4q5s
PubMed24973216
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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