Structure of PDB 4pxi Chain D Binding Site BS01

Receptor Information

>4pxi Chain D (length=193) Species: 1902 (Streptomyces coelicolor) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EQTRATIIGAAADLFDRRGYESTTLSEIVAHAGVTKGALYFHFAAKEDLA
HAILEIQSRTSRRLAKDLDYSSLEALMRLTFGMARLCVQGPVLRAGLRLA
TAGVPVRLPHPFTEWREIATSRLLDAVRQSDVHQDIDVDSVAHTLVCSVV
GTRVAGREPRRLAEMWYILIRGMVPVTRRARYVTLAARLEQET

Ligand information

>4pxi Chain E (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

atacgggacgccccgtttat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4pxi Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2)
Resolution	3.2 Å
Binding residue (original residue number in PDB)	T31 L32 K43 Y47 A52 K53
Binding residue (residue number reindexed from 1)	T24 L25 K36 Y40 A45 K46
Binding affinity	PDBbind-CN: Kd=200nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Biological Process

External links

PDB	RCSB:4pxi, PDBe:4pxi, PDBj:4pxi
PDBsum	4pxi
PubMed	25092919
UniProt	O66122

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