Structure of PDB 4oav Chain D Binding Site BS01

Receptor Information
>4oav Chain D (length=674) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV
ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG
FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA
AEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLL
LDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT
ALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGA
KEWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGF
YEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVC
VTLCEQTLEACLDVNEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN
ILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE
DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE
SRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECV
MKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEMKLKIGDPSLYFQKT
FPDLVIYVYTKLQNTEYRKHFPQT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4oav Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E55 E56 E57 G58 W60 Q68 K89 N91 Y124 F126 E131 Y135 R155 K166 R203
Binding residue
(residue number reindexed from 1)		E30 E31 E32 G33 W35 Q43 K64 N66 Y99 F101 E106 Y110 R130 K141 R178
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019843 rRNA binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0043488 regulation of mRNA stability
GO:0045071 negative regulation of viral genome replication
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of D-glucose import
GO:0051607 defense response to virus
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016363 nuclear matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4oav, PDBe:4oav, PDBj:4oav
PDBsum4oav
PubMed24578532
UniProtQ05823|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

[Back to BioLiP]