Structure of PDB 4o2w Chain D Binding Site BS01

Receptor Information

>4o2w Chain D (length=364) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANG
TVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA
LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS
AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN
HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVAC
GTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDV
AVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVR
QISAGRCHSAAWTA

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4o2w Chain D Residue 4401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4o2w Crystal structure of the third RCC1-like domain of HERC1
Resolution	2.0 Å
Binding residue (original residue number in PDB)	D4213 D4215
Binding residue (residue number reindexed from 1)	D217 D219
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.26: HECT-type E3 ubiquitin transferase.

External links

PDB	RCSB:4o2w, PDBe:4o2w, PDBj:4o2w
PDBsum	4o2w
PubMed
UniProt	Q15751\|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 (Gene Name=HERC1)

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