Structure of PDB 4nnd Chain D Binding Site BS01

Receptor Information
>4nnd Chain D (length=281) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSARSFLERLEAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRY
KDVLPYDQTRVILSLLQEEHSDYINGNFIRGVDGSLAYIATQGPLPHTLL
DFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIK
EKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEE
ARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDV
VLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4nnd Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Resolution2.502 Å
Binding residue
(original residue number in PDB)		Y62 K63 D64 R140 D197 R198 S229 S230 A231 C233 R235 Q276
Binding residue
(residue number reindexed from 1)		Y50 K51 D52 R127 D184 R185 S216 S217 A218 C220 R222 Q263
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nnd, PDBe:4nnd, PDBj:4nnd
PDBsum4nnd
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

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