Structure of PDB 4mvl Chain D Binding Site BS01

Receptor Information

>4mvl Chain D (length=171) Species: 9606 (Homo sapiens)

LIPAPPLSKVPLQQNFQDNQFHGKWYVVGAAGNVLLREDKDPLKMYATIY
ELKEDKSYNVTSVGFDDKKCLYKIRTFVPGSQPGEFTLGRIKSEPGGTSW
LVRVVSTNYNQHAMVFFKEVAQNRETFNITLYGRTKELTSELKENFIRFS
KSLGLPENHIVFPVPIDQCID

Ligand information

>4mvl Chain H (length=9) Species: 9606 (Homo sapiens)

VFFAEDVGS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4mvl High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): L49 Y52 T54 S68 D72 L77 R81 L94 W106 F123 N134 Y138 P169
• Binding residue (residue number reindexed from 1): L43 Y46 T48 S62 D66 L71 R75 L88 W100 F117 N128 Y132 P163

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005515 protein binding
• GO:0036094 small molecule binding
• GO:0042802 identical protein binding
• GO:0140315 iron ion sequestering activity
• GO:1903981 enterobactin binding

Biological Process

• GO:0006826 iron ion transport
• GO:0006915 apoptotic process
• GO:0015891 siderophore transport
• GO:0042742 defense response to bacterium
• GO:0045087 innate immune response
• GO:0120162 positive regulation of cold-induced thermogenesis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0031410 cytoplasmic vesicle
• GO:0035580 specific granule lumen
• GO:0060205 cytoplasmic vesicle lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:4mvl, PDBe:4mvl, PDBj:4mvl
• PDBsum: 4mvl
• PubMed: 27029347
• UniProt: P80188|NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (Gene Name=LCN2)