Structure of PDB 4lip Chain D Binding Site BS01

Receptor Information

>4lip Chain D (length=319) Species: 292 (Burkholderia cepacia)

DNYAATRYPIILVHGLTGTDKYAGVLEYWYGIQEDLQQRGATVYVANLSG
FQSDDGPNGRGEQLLAYVKTVLAATGATKVNLVGHSQGGLTSRYVAAVAP
DLVASVTTIGTPHRGSEFADFVQGVLAYDPTGLSSTVIAAFVNVFGILTS
SSNNTNQDALAALKTLTTAQAATYNQNYPSAGLGAPGSCQTGAPTETVGG
NTHLLYSWAGTAIQPTISVFGVTGATDTSTIPLVDPANALDPSTLALFGT
GTVMVNRGSGQNDGVVSKCSALYGQVLSTSYKWNHLDEINQLLGVRGANA
EDPVAVIRTHANRLKLAGV

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4lip Chain D Residue 321

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4lip Structural basis of the chiral selectivity of Pseudomonas cepacia lipase
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): D242 D288 Q292 V296
• Binding residue (residue number reindexed from 1): D241 D287 Q291 V295
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.1.3: triacylglycerol lipase.

Gene Ontology

Molecular Function

• GO:0004806 triacylglycerol lipase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0016042 lipid catabolic process

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:4lip, PDBe:4lip, PDBj:4lip
• PDBsum: 4lip
• PubMed: 9660188
• UniProt: P22088|LIP_BURCE Triacylglycerol lipase (Gene Name=lip)