Structure of PDB 4lgt Chain D Binding Site BS01

Receptor Information
>4lgt Chain D (length=247) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSEKLQKVLARAGHGSRREIESIIEAGRVSVDGKIAKLGDRVEVTPGLKI
RIDGHLISVRESICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARW
IAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKL
RDLSRGVQLEDGPAAFKTIKFSGGEGINQWYNVTLTEGRNREVRRLWEAV
GVQVSRLIRVRYGDIPLPKGLPRGGWTELDLAQTNYLRELVELPPET
Ligand information
>4lgt Chain E (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaacgucgugagacaguucg
.<.<<<<<....>>>.>>.>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4lgt The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		D150 R154
Binding residue
(residue number reindexed from 1)		D147 R151
Enzymatic activity
Enzyme Commision number 5.4.99.22: 23S rRNA pseudouridine(2605) synthase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
GO:0016866 intramolecular transferase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4lgt, PDBe:4lgt, PDBj:4lgt
PDBsum4lgt
PubMed24214967
UniProtP37765|RLUB_ECOLI Ribosomal large subunit pseudouridine synthase B (Gene Name=rluB)

[Back to BioLiP]