Structure of PDB 4j9u Chain D Binding Site BS01

Receptor Information
>4j9u Chain D (length=462) Species: 223926 (Vibrio parahaemolyticus RIMD 2210633) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQFRSIIRIVGLLLALFSVTMLAPALVALLYRDGAGVPFVTTFFVLLFCG
AMCWFPNRRHKHSRDGFLIVVLFWTVLGSAGSLPFLIADNPNISVTDAFF
ESFSALTTTGATVIVGLDELPKAILFYRQFLQWFGGMGIIVLAVAILPVL
GIGGMIAETAKALWYIYLSLTIACAVAFWLAGMTPFDAISHSFSTIAIGG
FSTHDASMGYFDSYAINLITVVFLLISACNFTLHFAAFASGGVHPKYYWK
DPEFRAFIFIQVLLFLVCFLLLLKHHSYTSPYDAFDQALFQTVSISTTAG
FTTTGFADWPLFLPVLLLFSSFIGGCAGSTGGGMKVIRILLLTLQGAREL
KRLVHPRAVYTIKVGGSALPQRVVDAVWGFFSAYALVFVVCMLGLIATGM
DELSAFSAVAATLNNLGPGLGEVALHFGDVNDKAKWVLIVSMLFGRLEIF
TLLILLTPTFWR
Ligand information
Ligand IDTBR
InChIInChI=1S/12BrH.6Ta/h12*1H;;;;;;/q;;;;;;;;;;;;;;;;;+1/p-1
InChIKeyYWYIQTPPCOBSGN-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0Br[Ta]123456Br[Ta]17891%10[Ta]22%11(Br7)[Ta]337%12%13([Ta]484([Ta]923(Br%11)(Br1)(Br4)(Br7)Br%12)(Br5)(Br%10)Br%13)Br6
CACTVS 3.370Br|1[Ta]|2|3|4|5|Br[Ta]|6|7|89%10|2|Br[Ta]|%11|%12|%13|%14|1|3|6Br|[Ta]|%15|%16|%17|7|%11(Br|[Ta]|%18|4|%12|%15(Br|%13)(Br|%14)|Br[Ta]|5|8|%16|%18(|Br9)(Br)Br|%17)|Br%10
FormulaBr12 Ta6
NameHEXATANTALUM DODECABROMIDE;
DODECABROMOHEXATANTALUM
ChEMBL
DrugBankDB04119
ZINC
PDB chain4j9u Chain D Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4j9u Gating of the TrkH ion channel by its associated RCK protein TrkA.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		L150 I178
Binding residue
(residue number reindexed from 1)		L147 I156
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015379 potassium:chloride symporter activity
GO:0030955 potassium ion binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0006813 potassium ion transport
GO:0030001 metal ion transport
GO:0034220 monoatomic ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4j9u, PDBe:4j9u, PDBj:4j9u
PDBsum4j9u
PubMed23598339
UniProtQ87TN7|TRKH_VIBPA Trk system potassium uptake protein TrkH (Gene Name=trkH)

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