Structure of PDB 4h25 Chain D Binding Site BS01

Receptor Information
>4h25 Chain D (length=180) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFA
SFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREP
NVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLP
FLPSTEDVYDCRVEHWGLDEPLLKHWEFDA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4h25 T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Q9 F24 A52 S53 F54 N62 V65 N69 E71 I72 M73 R76
Binding residue
(residue number reindexed from 1)		Q7 F22 A50 S51 F52 N60 V63 N67 E69 I70 M71 R74
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4h25, PDBe:4h25, PDBj:4h25
PDBsum4h25
PubMed23091041
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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