Structure of PDB 4gmj Chain D Binding Site BS01

Receptor Information
>4gmj Chain D (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RICEVWACNLDEEMKKIRQVIRKYNYVAMDTEFPGVVARPIGEFRSNADY
QYQLLRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTEDMYAQ
DSIELLTTSGIQFKKHEEEGIETQYFAELLMTSGVVLCEGVKWLSFHSGY
DFGYLIKILTNSNLPEEELDFFEILRLFFPVIYDVKYLMKSCKNLKGGLQ
EVAEQLELERIGPQHQAGSDSLLTGMAFFKMREMFFEDHIDDAKYCGHLY
GLGNAYEEE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4gmj Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gmj The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D40 E278
Binding residue
(residue number reindexed from 1)		D30 E257
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0004532 RNA exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0034584 piRNA binding
GO:0046872 metal ion binding
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006402 mRNA catabolic process
GO:0006417 regulation of translation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010629 negative regulation of gene expression
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0033962 P-body assembly
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0045070 positive regulation of viral genome replication
GO:0045892 negative regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061014 positive regulation of mRNA catabolic process
GO:0140991 piRNA-mediated gene silencing by mRNA destabilization
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0043232 intracellular non-membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gmj, PDBe:4gmj, PDBj:4gmj
PDBsum4gmj
PubMed22977175
UniProtQ9UIV1|CNOT7_HUMAN CCR4-NOT transcription complex subunit 7 (Gene Name=CNOT7)

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