Structure of PDB 4gez Chain D Binding Site BS01

Receptor Information

>4gez Chain D (length=365) Species: 1129346 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/164/2009(H17N10)))

YWRAKSQMCEVKGWVPTHRGFPWGPELPGDLILSRRAYVSCDLTSCFKFF
IAYGLSANQHLLNTSMEWEESLYKTPIGSASTLSTSEMILPGRSSSACFD
GLKWTVLVANGRDRNSFIMIKYGEEVTDTFSASRGGPLRLPNSECICIEG
SCFVIVSDGPNVNQSVHRIYELQNGTVQRWKQLNTTGINFEYSTCYTINN
LIKCTGTNLWNDAKRPLLRFTKELNYQIVEPCNGAPTDFPRGGLTTPSCK
MAQEKGEGGIQGFILDEKPAWTSKTKAESSQNGFVLEQIPNGIESEGTVS
LSYELFSNKRTGRSGFFQPKGDLISGCQRICFWLEIEDQTVGLGMIQELS
TFCGINSPVQNINWD

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4gez Chain D Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4gez Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): N284 D288 D314 G332 G334
• Binding residue (residue number reindexed from 1): N208 D212 D238 G256 G258
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): W144 Y268 T283 Q357 R389
• Catalytic site (residue number reindexed from 1): W68 Y192 T207 Q281 R313
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:4gez, PDBe:4gez, PDBj:4gez
• PDBsum: 4gez
• PubMed: 23012478
• UniProt: H6QM85