Structure of PDB 4g3h Chain D Binding Site BS01

Receptor Information
>4g3h Chain D (length=300) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQTITQERCVLY
KEFRYAKNFEDYYLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQA
FRSVHKDKKIGILYLDAHADIHTAIHGMPLGMVLNRVRSMSESEEKAWQK
LCSLGLEKGGLEIDPKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIREN
MQEVVQKTKESLKAVDIIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQ
LLGLLLESFKDRLKAVEVTEYNPTVSIKHNNEEEKQVLEILDLIINSCKI
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4g3h Chain D Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4g3h Structure and function studies on Helicobacter pylori arginase
Resolution2.2 Å
Binding residue
(original residue number in PDB)
H91 D116 D120 D234
Binding residue
(residue number reindexed from 1)
H91 D116 D120 D223
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H91 D116 H118 D120 H133 D234 D236 E281
Catalytic site (residue number reindexed from 1) H91 D116 H118 D120 H126 D223 D225 E270
Enzyme Commision number 3.5.3.1: arginase.
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006525 arginine metabolic process
GO:0019547 arginine catabolic process to ornithine
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4g3h, PDBe:4g3h, PDBj:4g3h
PDBsum4g3h
PubMed
UniProtO25949

[Back to BioLiP]