Structure of PDB 4f2r Chain D Binding Site BS01

Receptor Information
>4f2r Chain D (length=583) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPLAKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGR
FFLRPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFD
LLLAAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVL
AEHLVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGV
KVDTKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQ
LPVLKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLK
VVRPATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPS
ESDWLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVS
EDEVTPNMRRQAKAVNYGIVYGISDYGLAQNLNISRKEAAEFIERYFESF
PGVKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMN
TPIQGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMER
LCRLVPEVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4f2r Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Resolution1.63 Å
Binding residue
(original residue number in PDB)		T550 K551 T552 T556 A558 R578 K582 Y587 R615 Q624 N625 I626 P627 I628 R629 H829
Binding residue
(residue number reindexed from 1)		T257 K258 T259 T263 A265 R285 K289 Y294 R322 Q331 N332 I333 P334 I335 R336 H536
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4f2r, PDBe:4f2r, PDBj:4f2r
PDBsum4f2r
PubMed
UniProtQ5KWC1

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