Structure of PDB 4e45 Chain D Binding Site BS01

Receptor Information
>4e45 Chain D (length=74) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQA
QAEDALRVDVDQLEKVLPQLLLDF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4e45 Chain D Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4e45 Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q76 D80
Binding residue
(residue number reindexed from 1)		Q69 D73
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0006281 DNA repair
GO:0007059 chromosome segregation
GO:0031297 replication fork processing
GO:0031398 positive regulation of protein ubiquitination
GO:0036297 interstrand cross-link repair
GO:0051301 cell division
GO:0051382 kinetochore assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0000939 inner kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0043240 Fanconi anaemia nuclear complex
GO:0071821 FANCM-MHF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4e45, PDBe:4e45, PDBj:4e45
PDBsum4e45
PubMed
UniProtA8MT69|CENPX_HUMAN Centromere protein X (Gene Name=CENPX)

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