Structure of PDB 4dqq Chain D Binding Site BS01

Receptor Information
>4dqq Chain D (length=584) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKPLAKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHG
RFFLRPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSF
DLLLAAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPV
LAEHLVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAG
VKVDTKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKL
QLPVLKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLL
KVVRPATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVP
SESDWLIFAADYSQIALRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQV
SEDEVTPNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFES
FPGVKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAM
NTPIQGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEME
RLCRLVPEVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4dqq Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
Resolution1.595 Å
Binding residue
(original residue number in PDB)		T550 K551 T552 T556 S557 A558 R578 Y587 R615 Q624 N625 I626 P627 I628 R629 H829
Binding residue
(residue number reindexed from 1)		T258 K259 T260 T264 S265 A266 R286 Y295 R323 Q332 N333 I334 P335 I336 R337 H537
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4dqq, PDBe:4dqq, PDBj:4dqq
PDBsum4dqq
PubMed22648417
UniProtQ5KWC1

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