Structure of PDB 4dcp Chain D Binding Site BS01

Receptor Information
>4dcp Chain D (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKY
EVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP
VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTEFDCGIET
Ligand information
Receptor-Ligand Complex Structure
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PDB4dcp Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Resolution1.7 Å
Binding residue
(original residue number in PDB)		R1064 H1121 Q1161 C1163
Binding residue
(residue number reindexed from 1)		R31 H88 Q128 C130
Enzymatic activity
Catalytic site (original residue number in PDB) T1062 S1063 H1121 G1122 C1163 R1164
Catalytic site (residue number reindexed from 1) T29 S30 H88 G89 C130 R131
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dcp, PDBe:4dcp, PDBj:4dcp
PDBsum4dcp
PubMed22304005
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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