Structure of PDB 4cqn Chain D Binding Site BS01

Receptor Information
>4cqn Chain D (length=860) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHM
GHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPW
TYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVY
KKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYAD
ELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRP
DTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEK
KGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFAS
KYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIA
DKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQL
PVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYY
ARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRD
AGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGR
IVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFAS
PADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKA
LRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALM
QEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDST
LVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYV
PGKLLNLVVG
Ligand information
>4cqn Chain E (length=79) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggaugguggaaucgguagacacaagggauucccucggcgcgcgcug
ugcggguucaagucccgcuccggguacca
<<<<<<<..<<<...........>>>.<<<<<.>>>>>.<<<<..>>>>.
.<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB4cqn The Physiological Target for Leurs Translational Quality Control is Norvaline
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y43 G83 L84 A167 N168 E169 Q190 M219 N222 W223 A291 E292 A293 R416 R418 R424 R426 F493 E532 M536 M568 L570 M617 S618 K619 F648 A649 S650 P651 M654 G665 R668 K671 K711 R719 N723 A727 M730 E731 N734 L801 V803 Q805 K846 I848 V850 L854 N856
Binding residue
(residue number reindexed from 1)		Y43 G83 L84 A167 N168 E169 Q190 M219 N222 W223 A291 E292 A293 R416 R418 R424 R426 F493 E532 M536 M568 L570 M617 S618 K619 F648 A649 S650 P651 M654 G665 R668 K671 K711 R719 N723 A727 M730 E731 N734 L801 V803 Q805 K846 I848 V850 L854 N856
Enzymatic activity
Catalytic site (original residue number in PDB) F493 H533 F543 K619 K622
Catalytic site (residue number reindexed from 1) F493 H533 F543 K619 K622
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cqn, PDBe:4cqn, PDBj:4cqn
PDBsum4cqn
PubMed24935946
UniProtP07813|SYL_ECOLI Leucine--tRNA ligase (Gene Name=leuS)

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