Structure of PDB 4cn3 Chain D Binding Site BS01

Receptor Information
>4cn3 Chain D (length=78) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDDKDCLIDK
RQRNRCQYCRYQKCLAMGMKREAVQEER
Ligand information
Receptor-Ligand Complex Structure
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PDB4cn3 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		K145 H146 Y147 R164 Q206 E208 R209
Binding residue
(residue number reindexed from 1)		K14 H15 Y16 R33 Q75 E77 R78
Binding affinityPDBbind-CN: Kd=44nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn3, PDBe:4cn3, PDBj:4cn3
PDBsum4cn3
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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