Structure of PDB 4ch2 Chain D Binding Site BS01

Receptor Information
>4ch2 Chain D (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
>4ch2 Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB4ch2 Gpibalpha Interacts Exclusively with Exosite II of Thrombin
Resolution1.6 Å
Binding residue
(original residue number in PDB)		E328 G330 M331 P333 W334 F431 D433 H436 P437 C439 Y454 K455 R457 N484 M531 K532 P534 N537 R538 W539
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 F111 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 P207 N210 R211 W212
Enzymatic activity
Catalytic site (original residue number in PDB) H363 D419 E522 G523 D524 S525 G526
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ch2, PDBe:4ch2, PDBj:4ch2
PDBsum4ch2
PubMed24316004
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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