Structure of PDB 4c7o Chain D Binding Site BS01

Receptor Information
>4c7o Chain D (length=277) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKKIDDDLFEELEEQLLIADVGVETTRKIITNLTEGASRKQLRDAEALYG
LLKEEMGEILAKVDEPLNVEGKAPFVILMVGVNGVGKTTTIGKLARQFEQ
QGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIFDAIQ
AAKARNIDVLIADTAGRLQNKSHLMEELKKIVRVMKKLDVEAPHEVMLTI
DASTGQNAVSQAKLFHEAVGLTGITLTKLDGTAKGGVIFSVADQFGIPIR
YIGVGERIEDLRPFKADDFIEALFARE
Ligand information
>4c7o Chain E (length=48) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uguugguucucccgcaacgcggaagcgugugccgggauguagcuggca
<<<<<<<<.<<<<<<<<<<<....>>>>.>>>.>>>>...>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4c7o The Structural Basis of Ftsy Recruitment and Gtpase Activation by Srp RNA
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D165 A167 S168 F171 D172 K205 R208 V209 K212
Binding residue
(residue number reindexed from 1)		D140 A142 S143 F146 D147 K180 R183 V184 K187
Binding affinityPDBbind-CN: Kd~0.5uM
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane

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Molecular Function
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Biological Process
External links
PDB RCSB:4c7o, PDBe:4c7o, PDBj:4c7o
PDBsum4c7o
PubMed24211265
UniProtP10121|FTSY_ECOLI Signal recognition particle receptor FtsY (Gene Name=ftsY)

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