Structure of PDB 4bws Chain D Binding Site BS01

Receptor Information
>4bws Chain D (length=133) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKN
FAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINW
AMEDKQEMVDIIETVYRGARKGRGLVVSPKDYS
Ligand information
>4bws Chain E (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PLFQQRPYPSPGAVLRANAEASR
Receptor-Ligand Complex Structure
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PDB4bws Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G11 D15 I18 D68 F69 M72 Y73 E74 N87 H89 M91 N99 N100
Binding residue
(residue number reindexed from 1)		G7 D11 I14 D64 F65 M68 Y69 E70 N83 H85 M87 N95 N96
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bws, PDBe:4bws, PDBj:4bws
PDBsum4bws
PubMed24781215
UniProtP83876|TXN4A_HUMAN Thioredoxin-like protein 4A (Gene Name=TXNL4A)

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