Structure of PDB 4a0l Chain D Binding Site BS01

Receptor Information

>4a0l Chain D (length=355) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GQTSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRV
TSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKF
NQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQ
MLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVD
ATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIR
VYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLL
NDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNIL
IWNRE

Ligand information

>4a0l Chain T (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gctactcacgca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4a0l The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Resolution	7.4 Å
Binding residue (original residue number in PDB)	K168 P191 W236 W239 K280 P326 Q345 Q372 H373
Binding residue (residue number reindexed from 1)	K68 P91 W136 W139 K180 P226 Q245 Q272 H273

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

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External links

PDB	RCSB:4a0l, PDBe:4a0l, PDBj:4a0l
PDBsum	4a0l
PubMed	22118460
UniProt	Q2YDS1\|DDB2_DANRE DNA damage-binding protein 2 (Gene Name=ddb2)

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