Structure of PDB 4a0b Chain D Binding Site BS01

Receptor Information

>4a0b Chain D (length=355) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GQTSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRV
TSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKF
NQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQ
MLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVD
ATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIR
VYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLL
NDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNIL
IWNRE

Ligand information

>4a0b Chain I (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggtgaattagcag

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4a0b The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation
Resolution	3.8 Å
Binding residue (original residue number in PDB)	R148 K168 P191 W239 K280 V299 Q345 Q370 Q372 H373
Binding residue (residue number reindexed from 1)	R48 K68 P91 W139 K180 V199 Q245 Q270 Q272 H273

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

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Cellular Component

External links

PDB	RCSB:4a0b, PDBe:4a0b, PDBj:4a0b
PDBsum	4a0b
PubMed	22118460
UniProt	Q2YDS1\|DDB2_DANRE DNA damage-binding protein 2 (Gene Name=ddb2)

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