Structure of PDB 3us0 Chain D Binding Site BS01

Receptor Information

>3us0 Chain D (length=192) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MASPSNTDYPGPHSFDVSFQATWTYSTELKKLYCQIAKTCPIQIKVMTPP
PQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEG
NSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRR
PILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRK

Ligand information

>3us0 Chain E (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aaacatgtttataaacatgttt

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3us0 Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	S272 R279 R304 A307 R311
Binding residue (residue number reindexed from 1)	S142 R149 R174 A177 R181

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:3us0, PDBe:3us0, PDBj:3us0
PDBsum	3us0
PubMed	22247550
UniProt	Q9H3D4\|P63_HUMAN Tumor protein 63 (Gene Name=TP63)

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