Structure of PDB 3tr5 Chain D Binding Site BS01

Receptor Information
>3tr5 Chain D (length=508) Species: 777 (Coxiella burnetii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEKQTAMRRTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTIKHATSDWME
LEKQRSVTTSVMQFPYKDYLINLLDTPGHADFTEDTYRTLTAVDSALMVI
DAAKGVEPRTIKLMEVCRLRHTPIMTFINKMDRDTRPSIELLDEIESILR
IHCAPVTWPIGMGKYFKGIYHLIEDAIYLYQPGSERIEGINNPELDKKLG
DLASELRNEIELVKGASHPFEREGYLKGELTPIFFGSAINNFGVGELLDA
FVKEAPPPQGRETNSRLVKPEEEKFSGFVFKIQANMDPGHRDRIAFLRIA
SGQYQKGMKAYHVRLKKEIQINNALTFMAGKRENAEEAWPGDIIGLHNHG
TIQIGDTFTQGERFKFTGIPNFASELFRLVRLKDPLKQKALLKGLTQLSE
EGATQLFRPLDSNELILGAVGLLQFDVVAYRLENEYNVKCVYESVNVVTA
RWVICDDKAVLERFNQEQSRNLAYDGGGHLTYLAPSRVNLEITMEKWPEI
QFSETREH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3tr5 Chain D Residue 526 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3tr5 Structural genomics for drug design against the pathogen Coxiella burnetii.
Resolution2.11 Å
Binding residue
(original residue number in PDB)		Q370 Q414 E417
Binding residue
(residue number reindexed from 1)		Q353 Q397 E400
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D20
Catalytic site (residue number reindexed from 1) D18
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016149 translation release factor activity, codon specific
GO:0016150 translation release factor activity, codon nonspecific
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3tr5, PDBe:3tr5, PDBj:3tr5
PDBsum3tr5
PubMed26033498
UniProtQ83DC7|RF3_COXBU Peptide chain release factor 3 (Gene Name=prfC)

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