Structure of PDB 3pma Chain D Binding Site BS01

Receptor Information
>3pma Chain D (length=259) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDI
ALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTT
SVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDA
CEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDRLGS
Ligand information
>3pma Chain C (length=29) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKQVQDQTEKELFESYIE
Receptor-Ligand Complex Structure
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PDB3pma Interaction of thrombin with sucrose octasulfate.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E23 G25 L26 P28 W29 D116 H119 P120 C122 F134 K135 R137 N159 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 G10 L11 P13 W14 D113 H116 P117 C119 F134 K135 R137 N164 K212 R218 W219
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pma, PDBe:3pma, PDBj:3pma
PDBsum3pma
PubMed21736375
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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